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INOVOTION has developed a unique, highly sensitive and reproducible assay. It is applicable to all preclinical oncology and immuno-oncology drug discovery programs, and monitors the growth and metastatic dissemination of human tumor cells.
Our extensively-tested assays are an intermediate in vivo step in your drug discovery process that will save you time and money. INOVOTION's technology is an excellent optimisation to improve the efficiency of the classical drug discovery process, as shown by several scientific publications and over 600 R&D client studies.
We use the chicken egg model involving an enhanced chorioallantoic membrane xenograft technique which has proven extremely valuable for in vivo studies of tumor development, angiogenesis and malignant cell dissemination and mecanisms of cancer analysis.
INOVOTION's technology consists in a CAM assay grafting human cancer cells in the chicken egg environment. This is particularly suitable for tumor development due to the abundance of growth factors in the highly vascularized CAM. The chicken egg model allows rapid studies and requires a minute quantity of compounds. In the embryonic environment, the tumor grows rapidly.
OUR PRECLINICAL IN VIVO MODEL'S MAIN ADVANTAGES:
INOVOTION’s technology has been validated for over 55 human tumor cell lines, including carcinomas, gliomas and melanomas, as well as over 30 reference drugs currently on the market. Using these assays, we can investigate the efficacy and toxicity of new drugs, which are lead candidates in oncology. These assays can also be used to study genetically modified cell lines and target validation.
A LARGE RANGE OF STUDY POSSIBILITIES:
A RAPID AND PREDICTIVE IN VIVO XENOGRAFT ASSAY :
Our technology is a xenograft that uses embryonated eggs instead of mice to grow human tumors.
We graft human cancer cells on the chicken CAM, which are the same cell lines or PDX used in the mouse model. This is why our tests are as predictive as those in mice.
The tumors are grown for 10 days, and follow the rapid but physiological growth of the embryo.
We grow tumors of sizes comparable to those obtained with the mouse model.
If the cell lines used are invasive, we detect metastatic invasion in the lower CAM as well as in all targeted organs.
During this 10-day period, we can treat the embryo with experimental, such as immuno-oncology agents, small molecules, antibodies, peptides. We can then compare their effects with control and reference molecules.
CONTACT US and find out how Inovotion can meet your needs!
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