Metastasis: The #1 Cause of Cancer Mortality—But Still a Black Box in Drug Development

At INOVOTION, we’re tackling one of oncology’s greatest challenges: modeling metastasis early and effectively. Our CAM (Chorioallantoic Membrane) model offers a unique, ethical, and highly predictive in vivo platform to study tumor dissemination, invasion, and spontaneous metastasis—delivering real-time biological insights while reducing animal use.

Recent peer-reviewed studies and conference presentations have validated Inovotion’s NAM CAM model as a game-changer for preclinical oncology, especially in the fields of metastasis, stemness, and mitochondrial metabolism.

Key Highlights:

Mitochondrial DNA Drives Stemness & Metastasis
High mtDNA content boosts stemness, proliferation, migration, and metastatic potential in vivo.
Mauro-Lizcano M et al., Cell Death Dis. (2024)

ATP-High Cancer Cells: Therapy Resistance & Spread
ATP-rich subpopulations are the most aggressive and drug-resistant—CAM assays confirm that targeting ATP production can curb metastasis.
Fiorillo M et al., Front Oncol. (2021)

Targeting ATP Synthase to Block Metastasis
Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis by targeting ATP synthase—CAM model tracks these effects in vivo.
Fiorillo M et al., Cell Death Differ. (2021)

Eradicating Cancer Stem Cells with MTDR
MitoTracker Deep Red (MTDR) shows potent anti-CSC and anti-metastatic activity in CAM-based experiments.
Sargiacomo C et al., Front Oncol. (2021)

A Novel Doxycycline Derivative Prevents Metastasis
Doxy-Myr, a new antibiotic derivative, selectively targets CSCs and prevents spontaneous metastasis—validated in the CAM model.
Ózsvári B et al., Front Oncol. (2020)

These studies confirm: the CAM model is a powerful, real-time tool for monitoring tumor invasion, stemness, and metastatic potential—making it essential for early screening of anti-metastatic agents.

👉 Want to accelerate your oncology pipeline with more predictive, ethical, and cost-effective in vivo models?
Learn more about our platform: https://www.inovotion.com

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