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Efficacy & Toxicity

Target Validation

Toxicity Assays

Multi Cancer Screening

Apr 19 2023

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An innovative in vivo model for anti-tumor vaccine development: Safety validation and preliminary efficacy evaluation of a new antitumor vaccine STC-1010 on human colorectal adenocarcinoma using the chicken CAM assay

Authors:

Yan Wang, Arnaud Peyronnier, Benoît Pinteur, Lionel Chalus, Corinne Tortorelli, Paul Bravetti, Jean Viallet, François Ghiringhelli

Abstract:

Colorectal cancer (CRC) is the second cause of cancer-related death worldwide. Recent tremendous progresses have installed immunotherapy as a treatment option and opened multiple ways to address therapeutic challenges for MSI or MSS CRC patients. Accordingly, Brenus-Pharma developed a therapeutic cancer vaccine, the STC-1010, basing on the technology by stimulating tumor cells (STC) with physical (irradiation and heat shock) and chemical (via standard-of-care (SoC) chemotherapy) stress, coupled with the haptenization for overexpressing tumor-related antigens. Xenografts on the chicken embryo's ChorioAllantoic Membrane (CAM) have proven extremely valuable for in vivo studies in cancerology. In this work, we evaluated in vivo the anti-tumor efficacy of the STC-1010 vaccine using Inovotion's CAM assay.

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