INOVOTION has collaborated with multiples research teams, and the publications cited provide information about INOVOTION's technology. However if you have any questions or comment, feel free to contact us, our scientific team will be delighted to help you.

 

PUBLICATIONS
  • Collery P, Prunier C, Dosda E, Viallet J, Harikrishnan A; Veena V, Desmaele D
    Effectiveness of Rhenium(I)-diselenoether Low Doses in a Triple-negative Breast Cancer Chicken Embryo Model
    Anticancer Res. 2024 Mar;44(3):941-951. doi: 10.21873/anticanres.16889.
    PMID: 38423662

    Pubmed

 

  • Barthelemy D, Lescuyer G, Geiguer F, Grolleau E, Gauthier A, Balandier J, Raffin M, Bardel C, Bouyssounouse B, Rodriguez-Lafrasse C, Couraud S, Wozny AS, Payen L.
    Paired Comparison of Routine Molecular Screening of Patient Samples with Advanced Non-Small Cell Lung Cancer in Circulating Cell-Free DNA Using Three Targeted Assays
    Cancers (Basel). 2023 Mar 3;15(5):1574. doi: 10.3390/cancers15051574.
    PMID: 36900363

    Pubmed

 

  • Dutriaux A, Diazzi S, Bresesti C, Hardouin S, Deshayes F, Collignon J, Flagiello D.
    LADON, a Natural Antisense Transcript of NODAL, Promotes Tumour Progression and Metastasis in Melanoma
    Noncoding RNA. 2023 Nov 15;9(6):71. doi: 10.3390/ncrna9060071.PMID: 37987367
    Pubmed
     

 

  • Fischer D, Fluegen G, Garcia P, Ghaffari-Tabrizi-Wizsy N, Gribaldo L, Huang RY, Rasche V, Ribatti D, Rousset X, Pinto MT, Viallet J, Wang Y, Schneider-Stock R.
    The CAM Model – Q&A with Experts
    Cancers (Basel). 2022 Dec 28;15(1):191. doi: 10.3390/cancers15010191. PMID: 36612187
    Pubmed
     

 

  • Desette A, Guichet PO, Emambux S, Masliantsev K, Cortes U, Ndiaye B, Milin S, George S, Faigner M, Tisserand J, Gaillard A, Brot S, Wager M, Tougeron D, Karayan-Tapon L.
    Deciphering Brain Metastasis Stem Cell Properties From Colorectal Cancer Highlights Specific Stemness Signature and Shared Molecular Features
    Cell Mol Gastroenterol Hepatol. 2023;16(5):757-782. doi: 10.1016/j.jcmgh.2023.07.008. Epub 2023 Jul 22.
    PMID: 37482243

    Pubmed
     

 

  • Hatat AS, Benoit-Pilven C, Pucciarelli A, de Fraipont F, Lamothe L, Perron P, Rey A, Levra MG, Toffart AC, Auboeuf D, Eymin B, Gazzeri S.
    Altered splicing of ATG16-L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non-small cell lung cancer
    Mol Oncol. 2022 Oct;16(19):3490-3508. doi: 10.1002/1878-0261.13229. Epub 2022 Aug 30.
    PMID: 35593080

    Pubmed
     

 

  • Feliz Morel ÁJ, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, Aouad A, Cogoluegnes S, Favier J, Pasquier C, Mus-Veteau I.
    Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched
    Pharmaceutics. 2022 May 5;14(5):988. doi: 10.3390/pharmaceutics14050988.
    PMID: 35631574

    Pubmed
     

 

  • Rousset X, Maillet D, Grolleau E, Barthelemy D, Calattini S, Brevet M, Balandier J, Raffin M, Geiguer F, Garcia J, Decaussin-Petrucci M, Peron J, Benzerdjeb N, Couraud S, Viallet J, Payen L.
    Embryonated Chicken Tumor Xenografts Derived from Circulating Tumor Cells as a Relevant Model to Study Metastatic Dissemination: A Proof of Concept
    Cancers (Basel). 2022 Aug 23;14(17):4085. doi: 10.3390/cancers14174085.
    PMID: 36077622

    Pubmed

 

  • Wang Y, Rousset X, Prunier C, Garcia P, Dosda E, Leplus E, Viallet J.
    PD-1/PD-L1 Checkpoint Inhibitors Are Active in the Chicken Embryo Model and Show Antitumor Efficacy In Ovo.
    Cancers (Basel). 2022 Jun 23;14(13):3095. doi: 10.3390/cancers14133095.
    Pubmed

 

  • Feliz Morel ÁJ, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, Aouad A, Cogoluegnes S, Favier J, Pasquier C, Mus-Veteau I. 
    Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched
    Pharmaceutics. 2022 May 5;14(5):988. doi: 10.3390/pharmaceutics14050988.
    PMID: 35631574

    Pubmed

 

  • Mark W Nachtigal, Paris Musaphir, Shiv Dhiman, Alon D Altman, Frank Schweizer, Gilbert Arthur 
    Cytotoxic capacity of a novel glycosylated antitumor ether lipid in chemotherapy-resistant high grade serous ovarian cancer in vitro and in vivo
    Transl Oncol.2021 Nov;14(11):101203. doi: 10.1016/j.tranon.2021.101203. Epub 2021 Aug 17
    Pubmed

 

  • Paul Garcia, Jean Viallet, Yan Wang, Zuzana Macek Jilkova
    The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies
    Front. Immunol., 19 November 2021
    Pubmed

 

  • Marco Fiorillo, Béla Ózsvári, Federica Sotgia, Michael P Lisanti
    High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy
    Frontiers in Oncology. 2021 October 15
    Pubmed

 

  • Fiorillo M, Scatena C, Naccarato AG, Sotgia F, Lisanti MP.
    Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase.
    Cell Death Differ. 2021 Sep;28(9):2797-2817. doi: 10.1038/s41418-021-00788-x. Epub 2021 May 13.
    PMID: 33986463

    Pubmed

 

  • Kimani S, Chakraborty S, Irene I, de la Mare J, Edkins A, du Toit A, Loos B, Blanckenberg A, Van Niekerk A, Costa-Lotufo LV, ArulJothi KN, Mapolie S, Prince S.
    The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity
    Biochem Pharmacol. 2021 Aug;190:114598. doi: 10.1016/j.bcp.2021.114598. Epub 2021 May 9.
    PMID: 33979647

    Pubmed

 

  • Sargiacomo C, Stonehouse S, Moftakhar Z, Sotgia F, Lisanti MP.
    MitoTracker Deep Red (MTDR) Is a Metabolic Inhibitor for Targeting Mitochondria and Eradicating Cancer Stem Cells (CSCs), With Anti-Tumor and Anti-Metastatic Activity In Vivo
    Front Oncol. 2021 Jul 30;11:678343. doi: 10.3389/fonc.2021.678343. eCollection 2021.
    PMID: 34395247

    Pubmed

 

  • Byrgazov K, Besse A, Kraus M, Slipicevic A, Lehmann F, Driessen C, Besse L.
    Novel Peptide-drug Conjugate Melflufen Efficiently Eradicates Bortezomib-resistant Multiple Myeloma Cells Including Tumor-initiating Myeloma Progenitor Cells
    Hemasphere. 2021 Jun 12;5(7):e602. doi: 10.1097/HS9.0000000000000602. eCollection 2021 Jul.
    PMID: 34136753

    Pubmed

 

  • Marcion G, Hermetet F, Neiers F, Uyanik B, Dondaine L, Dias AMM, Da Costa L, Moreau M, Bellaye PS, Collin B, Gobbo J, Briand L, Seigneuric R, Kitten O, Cinier M, Garrido C.
    Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer.
    Int J Cancer. 2021 Jun 15; 148(12):3019-3031
    Pubmed

 

  • Ózsvári B, Magalhães LG, Latimer J, Kangasmetsa J, Sotgia F, Lisanti MP.
    A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity.
    Front Oncol. 2020 Sep 15;10:1528. doi: 10.3389/fonc.2020.01528. eCollection 2020.
    PMID: 33042796

    Pubmed

 

  • Byrgazov K, Anderson C, Salzer B, Bozsaky E, Larsson R, Gullbo J, Lehner M, Lehmann F, Slipicevic A, Kager L, Fryknäs M, Taschner-Mandl S.
    Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide.
    Ther Adv Med Oncol. 2020 Jul 29;12:1758835920937891. doi: 10.1177/1758835920937891. eCollection 2020.
    PMID: 32774473

    Pubmed

 

  • Leclair HM, Tardif N, Paris A, Galibert MD, Corre S.
    Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors.
    Int J Mol Sci. 2020 Jul 16;21(14):5025. doi: 10.3390/ijms21145025.
    PMID: 32708687

    Pubmed

 

  • Iman W. Achkar,Sara Kader, Shaima S. Dib, Kulsoom Junejo, Salha Bujassoum Al-Bader, Shahina Haya, Aditya M. Bhagwat, Xavier Rousset, Yan Wan, Jean Viallet, Karsten Suhre and Anna Halama
    Metabolic Signatures of Tumor Responses to Doxorubicin Elucidated by Metabolic Profiling in Ovo
    Metabolites 2020, 10(7), 268
    Pubmed

 

  • Laurie Signetti, Nelli Elizarov, Méliné Simsir, Agnès Paquet, Dominique Douguet, Fabien Labbal, Delphine Debayle, Audrey Di Giorgio, Valérie Biou, Christophe Girard, Maria Duca, Lionel Bretillon, Corine Bertolotto, Bernard Verrier, Stéphane Azoulay and Isabelle Mus-Veteau
    Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf Melanoma
    Cancers 2020, 12(6), 1500

    Pubmed

 

  • Brun S, Bassissi F, Serdjebi C, Novello M, Tracz J, Autelitano F, Guillemot M, Fabre P, Courcambeck J, Ansaldi C, Raymond E, Halfon P.
    GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.
    Invest New Drugs (2019 Feb 19) pp 1-11

    Pubmed

 

  • Nascimento BFO, Laranjo M, Pereira NAM, Dias-Ferreira J, Piñeiro M, Botelho MF, Pinho E Melo TMVD.
    Ring-Fused Diphenylchlorins as Potent Photosensitizers for Photodynamic Therapy Applications: In Vitro Tumor Cell Biology and in Vivo Chick Embryo Chorioallantoic Membrane Studies.
    ACS Omega. 2019 Oct 9;4(17):17244-17250.
    Pubmed

 

  • Alsamri H, El Hasasna H, Al Dhaheri Y, Eid AH, Attoub S, Iratni R.
    Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3.
    Front Oncol. 2019 Aug 8;9:743
    Pubmed

 

  • P. Gilson, M. Couvet, L. Vanwonterghem, M. Henry, J. Vollaire, V. Baulin, M. Werner, A. Orlowska, V. Josserand, F. Mahuteau-Betzer, L. Lafanechère, J-L. Coll, B. Busser, A. Hurbin.
    The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo.
    Biochemical Pharmacology (2018)
    Pubmed

 

  • Arafat K, Al Kubaisy E, Sulaiman S, Karam S, M, Al Natour Z, Hassan A, H, Attoub S.
    SMARCAD1 in Breast Cancer Progression.
    Cell Physiol Biochem. 2018;50(2):489-500. doi: 10.1159/000494163. Epub 2018 Oct 11.
    PMID: 30308496

    Pubmed

 

  • Gilson P, Josa-Prado F, Beauvineau C, Naud-Martin D, Vanwonterghem L, Mahuteau-Betzer F, Moreno A5, Falson P, Lafanechère L, Frachet V, Coll JL, Fernando Díaz J, Hurbin A, and Busser B.
    Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties.
    Sci Rep. 2017 Aug 31;7(1):10209. doi: 10.1038/s41598-017-09491-9.
    PMID: 28860487

    Pubmed

 

  • E. Al Kubaisy, K. Arafat, O. De Wever, A. H. Hassan, S. Attoub
    SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
    Expert Opinion on Therapeutic Targets (2016), 20:9, 1035-1043
    Pubmed

 

  • El Hasasna H, Saleh A, Samri HA, Athamneh K, Attoub S, Arafat K, Benhalilou N, Alyan S, Viallet J, Dhaheri YA, Eid A, Iratni R.
    Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways.
    Sci Rep. 2016 Feb 18;6:21144.

    Pubmed

 

  • Kroiss A, Vincent S, Decaussin-Petrucci M, Meugnier E, Viallet J, Ruffion A, Chalmel F, Samarut J, Allioli N.
    Androgen-regulated microRNA-135a decreases prostate cancer cell migration and invasion through downregulating ROCK1 and ROCK2.
    Oncogene. 2015 May 28;34(22):2846-55.
    Pubmed

 

  • Mikaelian I, Malek M, Gadet R, Viallet J, Garcia A, Girard-Gagnepain A, Hesling C, Gillet G, Gonzalo P, Rimokh R, Billaud M.
    Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β-independent mechanism.
    Cancer Res. 2013 Nov 15;73(22):6621-31.
    Pubmed

 

  • Al Dhaheri Y, Attoub S, Arafat K, Abuqamar S, Viallet J, Saleh A, Al Agha H, Eid A, Iratni R.
    Anti-metastatic and anti-tumor growth effects of Origanum majorana on highly metastatic human breast cancer cells: inhibition of NFκB signaling and reduction of nitric oxide production.
    PLoS One. 2013 Jul 10;8(7):e68808.
    Pubmed

 

  • Prudent R, Vassal-Stermann É, Nguyen CH, Mollaret M, Viallet J, Desroches-Castan A, Martinez A, Barette C, Pillet C, Valdameri G, Soleilhac E, Di Pietro A, Feige JJ, Billaud M, Florent JC, Lafanechère L.
    Azaindole derivatives are inhibitors of microtubule dynamics, with anticancer and anti-angiogenic activities.
    Br J Pharmacol. 2013 Feb;168(3):673-85.
    Pubmed

 

PATENTS

 

  • Kotora et al.
    15p-substituted estrone derivatives as selective inhibitors of 17p-hydroxysteoid-dehydrogenases, method of preparation and use thereof.
    WO2017/211330. December 14, 2017

 

  • Guedat and Miniou.
    Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent.
    WO2017/021216 A1. February 9, 2017

 

  • Lafanechère et al.
    5-Azaindole compounds with anticancer and antiangiogenic activities.
    WO2014/033597 A1. March 6, 2014.